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Consejo Superior de Investigaciones Cientificas, CSIC (Spanish National Research Council)

Consejo Superior de Investigaciones Cientificas, CSIC (Spanish National Research Council)
Spanish public research organisation with 126 centres covering all knowledge areas and highly active in collaborating with the industry.

The company in detail

Profile

The Spanish National Research Council (Consejo Superior de Investigaciones Científicas, CSIC) is the largest public research organisation in Spain. CSIC is a multidisciplinary organisation with 130 centres located nationwide and a workforce of 13000. CSIC files an average of 60 international (PCT) and 180 Spanish patent applications and signs more than 60 technology licenses each year.

The Deputy Vice-Presidency for Knowledge Transfer is CSIC’s gateway for companies, ranging from SMEs to multinationals. We facilitate the appropriate contacts and are responsible for the cooperation with the industry, through research contracts and license agreements.

Some examples of our commitment to collaborate with companies in the field of Life Sciences are:

 √  Researchers at CSIC developed a method for DNA amplification based on a polymerase of the bacteriophage Phi29. This enzyme is particularly suitable for whole genome amplification from minute amounts of biological samples. Besides, the method works at mild temperature with no need of heating / cooling cycles. Different kits are marketed by GE Healthcare and QIAGEN under a patent license agreement with CSIC and are widely used for genetic analyses in research, testing and forensics.

 √  Gluten is a protein mixture present in several cereals which is toxic to celiacs. Nowadays gluten can be found in many processed foods and therefore a reliable test to measure its content is an absolute requirement for celiacs to ensure a long-life gluten-free diet. CSIC has developed an immunological test that is being assessed by the FAO and the WHO for replacement of its current Codex Alimentarius standard, thus paving its way to become the worldwide official technique to certify gluten-free food producers. CSIC’s technique is already endorsed by many associations of celiacs and thus four European companies successfully market kits for gluten measurement under a license agreement with CSIC.

 √  CSIC collaborated with Innogenetics N.V. (Belgium) and several research institutions and universities from Spain, Italy and the UK to develop an ELISA method to detect the Maedi-Visna virus. The patented method is licensed to the French company Hyphen and thus farmers have now a reliable tool to detect this virus, which may cause chronic pneumonia, mastitis, encephalitis and arthritis in sheep.

In summary, whether you are looking for technology licenses, collaborative research and development, research under contract, technological services, or any other form of interaction with a key player in research and innovation in Cancer, Infectious and Cardiovascular diseases, Physiopathology, Immunology, Neurobiology, Genomics and Proteomics, Diagnosis techniques, Molecular and Structural biology, Veterinary biosciences, Industrial biotechnology and bio-processing, Biopharmaceutical development, Bioremediation, Bioinformatics, Biophysics, Plant biotechnology, Agricultural science, Food science and technology and other Life Sciences areas, we will be glad of hearing from you.

Partnering strategy/interests

CSIC looks for mutually fruitful collaborations based upon licensing of knowledge (mainly patents, but also know-how, biological materials, etc), research contract and, to a lesser extent, joint ventures (including by generation of "spin-off" companies together with external stakeholders).

We very much prefer working with companies using a licensing approach to establish long-term collaborations with our researchers, but are also willing to make deals involving just licensing.

Out-licensing

The disposable biosensor detect pneumococcus (causes pneumonia, otitis, peritonitis, meningitis and septicaemia) in body fluids samples: blood, urine, cerebral spinal fluid, pleural fluid, and samples from nose, pharynx and eye More
Food allergies to fish or cephalopods can be triggered by antigens remaining after treatments to prevent parasitic diseases caused by Anisakis. We have developed an extraction and immunology method to detect these allergens in frozen and cooked food More
We have shown that measurement of anti-CD38 IgG antibodies in plasma or in peripheral blood mononuclear cells (including lymphocytes T) is applicable to diagnosis and prognosis of systemic lupus erythematosus More
CSIC has developed a magnetic nanoparticle which contains at least an active ingredient, which can be used for the treatment of cancer. It can be injected intravenously and targeted to the region of interest using an external magnetic field. More
A method to diagnose Chagas disease by detecting serologic antibodies to proteins of the pathogen (2, 3 or 4 proteins depending on the aim). It allows assessing the clinical stage and the response to treatments, and earlier diagnosis in newborns. More
Method to diagnose Chagas disease by detecting serologic antibodies to a synthetic peptide as sole antigen. This method allows assessing the clinical stage of the disease and the response to drugs in Chagas patients with chronic cardiopathology symptoms More
The devices offer a wide range of nanomedicine applications, specifically for disease diagnostics inside cells and tissues and for drug delivery More
MGD3 monoclonal antibody binds human Dectin-1 with high affinity and regulates production of cytokines TNF-α and Interleukin-10. MGD3 has a potential therapeutic use on inflammatory diseases. More
The antibody detects a protein of Candida famata and is useful for detection of candidiasis and retinopathies in samples from blood, urine, aqueous humour, vitreous humour, and cerebral spinal fluid without interference from other species of Candida More
Transgenic mice for screening compounds with therapeutic potential against pain, hyper-thyroidism or obesity. These transgenic mice over-express DREAM, a transcriptional repressor More
A micro-device for single/multi-parameter measurement by combining a disposable microoptofluidic system coupled to a broadband light source and a spectral readout setup, to count and analyze labelled and non-labelled organic and inorganic particles More
A modified brucellosis vaccine expressing the fluorescent protein GFP allows distinguishing between infected and vaccinated animals, a feature that was not possible with previous vaccines. More
Lysosomal acid ceramidase alteration is related to Farber disease and probably to cancer. We offer a fast and sensitive (pmol) fluorimetry method – current methods use radioactivity – to measure its level, with no interferences from other ceramidases More
A plastic microdevice for the isolation-extraction of circulating tumour cells by means of ultrasounds, as a non-invasive tool for the detection of recurrent disease, for monitoring and therapy selection More
Robotized portable system to analyze multiple samples that allows the simultaneous detection of up to thousands different analytes in a single test. Applicable to liquid and samples More
We have identified specific apolipoprotein J isoforms whose levels increase up to 100% or decrease up to 50% in the serum of patients with newly acute myocardial infarction, within 6 hours of onset More
A fluorimetry method determining lysosomal acid ceramidase as biomarker for diagnosis of several types of cancer. It avoids interferences (e.g. with other ceramidases) and the use of radioactivity, is highly sensitive (pmol) and reduces the analysis time More
An ELISA using chimeric peptides for early diagnosis of rheumatoid arthritis. Tested in sera from 900 patients, it shows improved sensitivity and prognostic value, as it identified patients with aggressive disease and worked where other tests failed More
The RNA-dependent protein-kinase PKR has been identified as a marker to assess the response to the treatment of cancer with 5-Fluorouracil (5-FU) alone or combined with other drugs. This is particularly interesting for patients with colon or breast cancer More

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