Out-licensing

Capsaicin, the active ingredient found in red-hot peppers, is used mainly for the relief of chronic pain of rheumatoid arthritis and osteoarthritis

Capsaicin, the active ingredient found in red-hot peppers, is used mainly for the relief of chronic pain of rheumatoid arthritis and osteoarthritis.

Project status: The capsaicin patch developed by LTS is a flexible, rectangular patch with rounded corners with maximal surface area of 300 cm2 (smaller patches are possible) Due to its textile backing layer, the patch is one-way stretchable. It consists of a self adhesive matrix, containing capsaicin, below 0.5% in concentration, and exhibits a pleasant heat sensation and good adhesion.The intensity of the heat sensation can be varied in either direction by changing the capsaicin concentration.

The current formulation was tested for stability over 3 years indicating a stable patch formulation at room temperature.

Competitive advantage: The main advantages of a topical capsaicin patch compared with available products on the market such as ointments or creams are:

1. Application period (once per day),
2. Avoidance of direct contact with the capsaicin (a solid matrix containing capsaicin)
3. Easy handling (pre-determined application area)

Phase I/II

Available for licensing. LTS will perform further development in collaboration with a partner. Further activities in the development of the patch include scale up to pilot plan production, validation and if required a clinical study in humans.

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