Out-licensing

3D Microscopic Magnetic Resonance Angiography: Cerebromicrovascular Disease Examining and Diagnosis

We have described a steady-state R2-based and flow-independent microscopic MRA method for the in vivo visualization of the architecture of small vessels of the rat brain. The method simultaneously provides high-resolution 3D information on the cerebral anatomy, in vivo microvascular architecture, and CBV mapping, which can be used to evaluate pathological microvascular changes over time. The technique might be suitable for use as a routine tool for examining the microvasculature in clinical patients who are healthy or are affected by cerebrovascular disease.

Conclusion

The proposed 3D-R2-based MRA method, which employs 3D reconstruction techniques, can simultaneously provide high-resolution 3D information on the cerebral anatomy, in vivo microvascular architecture, and hemodynamic response. The spin-echo-based R2 is highly tolerant of imaging artefacts and its contrast is associated well with the microvasculature.

Relevance/Opportunity

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Preclinical