Out-licensing

Alkynyl Sugar Analogues for Labelling and Visualization of Glycoconjugates in Cells

Introduction/Background

Most of eukaryotic proteins are glycoproteins, and it is acknowledged that glycosylation process plays a central role in mediating protein function in living organisms. It is known that altered glycosylation is often associated with inflammation and cancer metastasis.

Aims/Hypothesis

Therefore, the detailed correlations between glycosylation and biological or pathological statuses are of great interest and may provide information for disease diagnosis and treatment.

Research

The invention relates to the development of new chemical tools to probe glycoproteins. Innovative sugar analogues are used to feed cells for incorporating into cellular glycoproteins by glycosyltransferases. With chemical functionality on sugar analogues, the labelled glycoproteins can thus be specifically tagged on fluorogenic/fluorescent or affinity probes for imaging or purification.

Conclusion

This invention adds a powerful technique to the glycosylation and glycoprotein analysis repertoire.

Relevance/Opportunity

Please enquire if you are interested in forming licensing or codevelopment partnerships quoting reference no. 28A-960214.

Preclinical