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Generation of a Transgenic Mouse Model of Frontotemporal Lobar Degeneration
Generation of a Transgenic Mouse Model of Frontotemporal Lobar Degeneration
Full description
Introduction/Background
Frontotemporal lobar degeneration (FTLD) is clinically associated with atrophy in the frontal lobe and temporal lobe of the brain.
Aims/Hypothesis
There is a need for an animal model to study FTLD.
Research
This invention relates to the generation of mice with overexpression of TAR DNA binding protein (TDP) in the forebrain, including the hippocampus, cortex and striatum. We have found that this kind of mice exhibited the impaired cognition and motor performances. We expect the animal model would be suitable for studying FTLD and may lead to development of new/better therapeutic approaches/agents in the future.
Conclusion
We have developed the only animal model of frontotemporal lobar degeneration.
Relevance/Opportunity
Please enquire quoting reference no.13A-980515 regarding licensing or codevelopment partnerships.
Frontotemporal lobar degeneration (FTLD) is clinically associated with atrophy in the frontal lobe and temporal lobe of the brain.
Aims/Hypothesis
There is a need for an animal model to study FTLD.
Research
This invention relates to the generation of mice with overexpression of TAR DNA binding protein (TDP) in the forebrain, including the hippocampus, cortex and striatum. We have found that this kind of mice exhibited the impaired cognition and motor performances. We expect the animal model would be suitable for studying FTLD and may lead to development of new/better therapeutic approaches/agents in the future.
Conclusion
We have developed the only animal model of frontotemporal lobar degeneration.
Relevance/Opportunity
Please enquire quoting reference no.13A-980515 regarding licensing or codevelopment partnerships.
Development status
Registered
Patent information
US pending
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Company details
Related technologies
Related categories
- Industry sector
- Animal health / Medical device
- Academic/Research / Medical device
- Medical device / Therapeutic device
- Therapeutic target
- Central Nervous System
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