Out-licensing

Nanoparticles that exhibit high epithelial uptake and transepithelial transport

Summary
Nanoparticle technologies provide novel means to deliver diagnostic and therapeutic agents across cellular barriers. However, the extent of delivery for even nanoparticles can be limiting for various modes of dosing, calling for approaches to enhance nanoparticle delivery. The specific chemistry of a particular nanoparticle can greatly enhance or reduce its ability to move
through various biological membranes. Innovative research at the University of Nebraska Medical Center has led to the development of nanoparticles that exhibit high epithelial uptake and transepithelial transport. This pharmaceutically relevant technology has multiple applications including noninvasive delivery of nanoparticles as well as any associated large or small molecule drugs, diagnostics, and imaging agents.

Market Value
The increased efficiency of delivery and retention of nanoparticles to intercellular receptors has wide applications with the use of anti-cancer agents, gene and protein expression, and signaling molecules such as hormones, retinoids, thyroxine, etc.

Features and Benefits
• Crosses BBB Without Receptor Mediation
• Can Carry Multiple Antioxidative Enzymes
• Useful in Additional CNS Disorders Involving Oxidative Damage
• Cost Effective

Early Stage

US Patent Application Published:

      US-2006-0134209 A1

UNeMed Corporation offers a variety of licensing options and collaborative development opportunities with the University of Nebraska Medical Center.