The present invention provides methods that allow for real time detection of endothelial dysfunction, particularly arterial endothelial dysfunction, in major blood vessels by imaging
microbubbles retained on vessel endothelium after microbubble injection. Since ultrasound typically destroys microbubbles, a low mechanical index pulse sequence scheme in a high frequency linear array transducer is used to detect retained microbubbles.
This invention will improve the outcome of individuals who are at risk to vascular disease through accurate detection of endothelium dysfunction, allowing for early therapeutic intervention.
Features and Benefits
• real-time detection of endothelial dysfunction
• non-invasive procedure
• direct visualization methods for more accurate diagnosis
US Patent Issued:
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